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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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人类早期胚胎中染色质状态的基重编程

Shenli Yuan1,2,3,4, Lei Gao2, Wenrong Tao1,5

  • 1Center for Reproductive Medicine, Shandong University, Jinan 250012, China.

National science review
|March 7, 2024
PubMed
概括

人类和小鼠的早期胚胎显示出明显的表观遗传重编程. 虽然两者都保留了母体DNA甲基化和父体H3K27me3的基因抑制,但人类表现出更多的父体特异性表观遗传状态,并且缺乏H3K27me3的印记.

关键词:
通过DNA甲基化.H3K27me3 在线阅读染色质可访问性 染色质可访问性表观遗传学 重编程人类胚胎人类胚胎

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