患有脏综合征的儿童的内皮功能障碍:一个横截面研究
Harapriya Das1, Amit Satapathy1, Joseph John1
1Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, IND.
Cureus
|March 7, 2024
概括
患有性综合征 (NS) 的儿童在缓解期间表现出持续的脂质不良症和趋向于较低的反应性高血症指数 (RHI),表明潜在的早期血管变化. 需要进一步的研究来证实这些发现在儿科NS患者.
科学领域:
- 儿科脏病学 儿科脏病学
- 心血管健康 心血管健康
- 血管生物学 血管生物学
背景情况:
- 患有性综合征 (NS) 的儿童面临心血管风险增加.
- 有限的研究存在于小儿NS的动脉硬和内皮功能.
- 确定这些儿童早产动脉样硬化的预测性风险因素至关重要.
研究的目的:
- 评估患有NS的儿童的动脉硬性和内皮功能.
- 测量动脉内心中介厚度 (cIMT) 和流量介导扩张 (FMD).
- 与对照组相比,预测儿科NS患者过早动脉样硬化的风险.
主要方法:
- 纳入了33名处于缓解期的NS儿童 (年龄为2-14岁) 和39名健康对照.
- 收集患者病史,进行体检,并进行人体测量测量.
- 测量了cIMT,口病和其他生理参数,包括反应性高血压指数 (RHI).
主要成果:
- 超过50%的患有NS的儿童在缓解期间表现出血脂不良.
- 在NS患者和对照人群之间,没有发现平均cIMT或口病的显著差异.
- 在患有NS的儿童中观察到较低RHI的趋势.
结论:
- 脱脂症在患有性综合征的儿童中很常见,即使在缓解期.
- 虽然cIMT和口病没有显著差异,但RHI在NS组显著较低.
- 这些发现表明小儿NS的潜在亚临床血管变化,需要进一步调查.
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