关于肠球菌分离物中的生物膜形成和与其抗生素耐药性模式的关联的研究
Pooja Nair1, Sathish Sankar2, P Neelusree1
1Department of Microbiology, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus
|March 7, 2024
概括
肠杆菌,常见的肠道细菌,由于抗生素耐药性,越来越多地导致医院感染. 这项研究发现,Enterococcus faecalis菌株对常见抗生素具有高耐药性,但生物膜形成较低.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 肠球菌是人类正常的肠道菌群.
- 它们是导致医院内感染的主要原因.
- 抗生素耐药性和毒性使肠球菌成为成功的病原体.
研究的目的:
- 评估临床肠球菌分离物中的生物膜形成.
- 为了确定这些菌株的抗菌素耐药性模式.
主要方法:
- 在6个月内从患者身上收集了临床样本.
- 通过生物化学测试确定了肠球菌种类.
- 通过Kirby-Bauer磁盘扩散和微板测试来确定抗生素敏感性.
主要成果:
- 隔离了九十个Enterococcus物种:70%的Enterococcus faecalis,28%的Enterococcus faecium,以及2%的Enterococcus gallinarum. 这两种菌.
- Enterococcus faecalis表现出比其他物种更高的抗药率.
- 对青素 (47%),安培素 (43%),高水平的 gentamicin (39%) 和 ciprofloxacin (36%) 观察到高耐药性.
- 一些菌株也表现出对万科米辛和线索利德的耐药性.
结论:
- Enterococcus faecalis表明抗菌素耐药性正在增加.
- 这种物种与其他肠球菌相比,具有较低的生物膜构造.
- 这些发现突出了对医院获得感染中Enterococcus faecalis的担忧.
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