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生物Prev-C - 开发和验证一个当代的前列腺癌风险计算器

Thomas Hermanns¹, Marian S Wettstein¹, Basil Kaufmann¹

¹Department of Urology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Frontiers in oncology

|March 7, 2024

概括

一个新的前列腺癌 (PCa) 风险计算器,BioPrev-C,准确地预测高等级的PCa. 这种工具提供了卓越的临床益处,可能减少许多男性不必要的前列腺活检.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗信息学医疗信息学

背景情况:

前列腺癌 (PCa) 诊断依赖于风险分层.
准确预测高档PCa对于及时干预至关重要.
现有的风险计算器在性能和临床实用性方面存在限制.

研究的目的:

开发和验证一种新的风险计算器,BioPrev-C,用于预测高等级PCa (格里森分数≥7).
评估BioPrev-C与现有工具的临床实用性和性能.

主要方法:

一个前性队列391名男性接受前列腺活检被用于模型开发.
一个多变量逻辑回归模型结合了临床和MRI数据 (PI-RADS).
外部验证和与SWOP-RC和PBCG-RC进行比较,使用AUC和决策曲线分析.

主要成果:

生物Prev-C在高等级PCa检测方面表现出很高的准确性 (AUC 0.88).
它的表现优于SWOP-RC (AUC为0.84) 和PBCG-RC (AUC为0.71).
与其他计算器 (≥30%) 相比,BioPrev-C在较低的值 (≥4%) 显示了临床净益.

结论:

生物Prev-C是一种新的,准确的,临床上有益的高度前列腺癌风险计算器.
它的卓越性能表明它可以显著减少不必要的前列腺活检.
该工具为接受前列腺活检的男性提供了改进的风险分层.

关键词:

活组织活检决策辅助器是什么意思诺莫格拉姆 (Nomograms) 是一个名字.前列腺癌是前列腺癌.前列腺特异抗原的前列腺特异抗原.

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