与非小细胞肺癌患者对基化疗反应相关的遗传变异:一个现场摘要和元分析
Hilary Sito1, Mohamad Ayub Khan Sharzehan1, Md Asiful Islam2
1UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
British journal of biomedical science
|March 7, 2024
概括
这项元分析确定了12种与非小细胞肺癌 (NSCLC) 患者基于的化疗反应相关的遗传变异. 这些发现提供了对NSCLC个性化治疗策略的见解.
科学领域:
- 药物遗传学 药物遗传学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 非小细胞肺癌 (NSCLC) 的治疗通常涉及基于的化疗 (PBC).
- 遗传变异正在越来越多地研究它们在PBC反应中的作用,但研究结果不一致.
- 需要进行全面的元分析来澄清这些关联.
研究的目的:
- 进行一项元分析,评估NSCLC患者遗传变异与PBC反应之间的关联.
- 为准确评估NSCLC治疗中的药物遗传学.
主要方法:
- 搜索了PubMed,Scopus和Web of Science数据库的相关研究,直到2021年5月15日.
- 包括研究报告的基因型/等位基因频率在NSCLC患者治疗PBC,分层通过响应.
- 不包括细胞系研究,动物模型,重复研究和非初级研究. 使用NOS和威尼斯标准评估可信度;使用Begg和Egger测试评估偏见.
主要成果:
- 分析了121篇与29478名受试者的出版物,专注于184种遗传变异.
- 在10个与PBC反应显著相关的基因中确定了12个基因变异 (例如,ERCC1,ERCC2,CYP1A1,GSTM1,XRCC1).
- 生物信息学分析表明XRCC1 rs1799782和CYP1A1 rs1048943.3的潜在功能影响.
结论:
- 这一元分析总结了影响NSCLCPBC反应的关键遗传变异.
- 这些发现有助于理解NSCLC治疗的药物遗传学.
- 这些见解可能有助于制定个性化治疗策略.
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