社交时差会影响运动量,并减弱对自愿运动训练的生理和代谢适应
Michael B Dial1, Elias M Malek1, Austin R Cooper1
1Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, Nevada, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|March 7, 2024
概括
社会时差 (SJL) 扰乱昼夜节律,导致小鼠体重增加和葡萄糖耐受性受损. 运动减轻了体重增加,但并非所有由SJL引起的代谢和性能缺陷.
科学领域:
- 时间生物学 时间生物学
- 运动生理学 运动生理学
- 代谢健康 代谢健康
背景情况:
- 社交时差 (SJL) 是睡眠和清醒时间表的不对齐,影响了大部分人口.
- 由SJL引起的慢性昼夜干扰与心脏代谢疾病风险增加有关.
- SJL对代谢健康和运动适应性的影响需要进一步研究.
研究的目的:
- 研究SJL对小鼠代谢健康,运动表现和骨肌肉适应的影响.
- 确定自愿运动是否可以抵消SJL的负面影响.
主要方法:
- 40只C57BL/6J小鼠被分为对照组和SJL组,以及静止和运动子组.
- 模拟SJL使用一个6周的协议,涉及重复的相延迟和光暗周期的进步.
- 运动包括自由使用跑步轮;进行了新陈代谢和性能测试.
主要成果:
- 与对照组相比,SJL小鼠的活动模式发生了变化,跑步距离缩短,体重明显增加.
- SJL损害了葡萄糖耐受性和禁食血糖水平,尽管运动部分恢复了这些参数.
- 运动表现和骨肌中的线粒体含量被SJL削弱,即使是自愿运动.
结论:
- SJL扰乱昼夜节律,导致小鼠的代谢和表现不良.
- 自愿运动可以部分缓解SJL诱导的一些代谢障碍,但不能完全防止对表现和适应的负面影响.
- 保持昼夜卫生对于健康和优化炼效益至关重要.
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