在慢性病中,常存记忆T细胞的同源抗原独立分化
Kyle H Moore1,2,3, Elise N Erman1,3, Amie M Traylor1
1Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
American journal of physiology. Renal physiology
|March 7, 2024
概括
居民记忆T细胞 (TRMs) 在慢性病 (CKD) 发育期间在脏中积累. 这些TRM可以独立于特定的抗原产生,这表明炎的新机制.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
背景情况:
- 居民记忆T细胞 (TRMs) 是组织居民免疫细胞,对防御至关重要,但也与慢性炎症有关.
- 在病,特别是慢性病 (CKD) 中,TRM的分化途径和作用尚不清楚.
研究的目的:
- 为了调查TRMs在脏中的存在和特征,在阿里斯托洛基酸 (AA) 诱导的CKD期间.
- 探索中TRM分化的机制,特别是它们是否抗原依赖.
主要方法:
- 在C57BL/6J和OT-1转基因小鼠中使用阿里斯托洛希克酸 (AA) 诱导CKD.
- 在治疗后的不同时间点使用流细胞计和单细胞RNA测序来分析脏免疫细胞概况.
- 对TRM标记物,转录因子和受体的评估.
主要成果:
- 在AA诱导的CKD小鼠的脏中发现了大量的TRMs.
- 这些脏TRM表达了特征性的TRM标记物和转录因子.
- 在OT-1转基因小鼠中发现了TRMs,表明它们的分化可以独立于同源抗原-T细胞受体相互作用.
结论:
- 在慢性病 (CKD) 期间,脏中存在居住记忆T细胞 (TRM).
- 脏中的TRM生成可以是抗原独立的,这表明非经典的途径.
- 对脏TRM及其分化机制的进一步研究对于了解脏疾病的发病过程至关重要.
相关概念视频
Cell-mediated Immune Responses
68.3K
Overview
68.3K
Cells of the Adaptive Immune Response
986
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
986
T Cell Activation and Clonal Selection
731
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
731
Special Features of Adaptive Immunity
816
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
816
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K


