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Updated: Jul 1, 2025

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来自急性髓性白血病细胞的小细胞外囊通过转移miR-221-3p促进白血病发生

Mengyu Li1, Guohuan Sun2, Jinlian Zhao3

  • 1State Key Laboratory of Experimental Hematology; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin.

Haematologica
|March 7, 2024
PubMed
概括

小型细胞外囊泡 (sEVs) 提供微RNA-221-3p,促进急性髓性白血病 (AML) 细胞生长,并损害干细胞分化. 这突出了sEV-miRNAs作为AML的潜在治疗点.

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