肌肉力量的全基因组多基因评分预测了常见疾病和寿命的风险:一项前性队列研究
Päivi Herranen1, Kaisa Koivunen1, Teemu Palviainen2
1Faculty of Sport and Health Sciences, Gerontology Research Center (GEREC), University of Jyväskylä, Jyväskylä, Finland.
概括
对较高肌肉强度的遗传倾向,通过手握强度的多基因得分 (PGS HGS) 来衡量,与非传染性疾病和死亡率的风险降低有关. 这种遗传因素对未来的健康不利因素提供了适度的保护.
科学领域:
- 遗传学和衰老研究研究
- 公共卫生和流行病学
背景情况:
- 研究了肌肉力量和健康结果的遗传倾向之间的关联.
- 利用手握强度的多基因分数 (PGS HGS) 来评估对肌肉力量的遗传影响.
研究的目的:
- 为了确定是否对更高肌肉力量的遗传倾向预测了与年龄相关的非传染性疾病的发生率.
- 为了检查遗传肌肉力量潜力和急性不良健康事件后的生存率之间的关系.
- 评估遗传肌肉力量对整体死亡率的影响.
主要方法:
- 分析了来自342,443名芬兰生物库参与者的数据 (FinnGen数据结10).
- 采用线性和考克斯回归模型来探索PGS HGS和27个临床终点之间的关联.
- 包括40至108岁的参与者,其基因型和健康登记数据结合在一起.
主要成果:
- 较高的PGS HGS与2%-10%降低了特定非传染性疾病和死亡率的风险有关.
- 与最低五分位数相比,PGS HGS五分位数最高的参与者对这些疾病的风险降低了5%至23%.
- 在PGS中增加1SD的HGS预测了女性的下体质指数,但不是男性;在急性事件后没有发现与改善生存率的关联.
结论:
- 支持更高肌肉力量的遗传因素提供了对未来健康问题的保护作用,尽管效果大小适度.
- 需要进一步的研究来探索生活方式因素如何与肌肉力量在疾病抵抗中的遗传倾向相互作用.
- 研究基于遗传肌肉力量潜力的生活方式行为的差异性影响至关重要.
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