慢性心力衰竭中骨病的患病率和预后影响 慢性心力衰竭与减少喷射分数
Nicolas Verheyen1, Johannes Schmid2, Ewald Kolesnik1
1Department of Internal Medicine, Division of Cardiology, University Heart Center, Medical University of Graz, Graz, Austria.
骨质疏松症和脊椎骨折 (VFs) 在心力衰竭中常见,减少排气分数 (HFrEF). VF独立预测心血管死亡和心力衰竭住院,突出骨疾病作为HFrEF中的关键并发症.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 慢性心力衰竭 (心力衰竭降低射出分数 - - HFrEF) 与骨代谢状态有关,增加骨质疏松症和骨折风险.
- 骨病在心力衰竭中的临床相关性缺乏前性研究.
研究的目的:
- 评估HFrEF患者骨质疏松症和脊椎骨折 (VFs) 的患病率.
- 评估骨质疏松症和VFs对HFrEF患者心血管结果的预后影响.
主要方法:
- 对205名有症状的HFrEF门诊患者 (LVEF<50%) 的前性单中心研究.
- 骨质疏松症通过双能X射线吸收计诊断 (T-score ≤-2.5).
- 脊椎骨折 (VFs) 使用脊柱X射线 (Genant得分) 进行评估.
主要成果:
- 骨质疏松症的患病率为15% (31名患者),VF的患病率为14% (29名患者).
- 总体而言,27% (55名患者) 患有骨质疏松症或VFs.
- 脊椎骨折 (VFs) 独立预测心血管死亡 (HR 2.82) 和恶化的心力衰竭住院治疗 (HR 2.39).
结论:
- 骨病影响大约27%的HFrEF患者.
- 脊椎骨折 (VFs) 与心血管死亡和心力衰竭住院的风险明显增加有关.
- 流行性骨病,特别是VF,是HFrEF中临床相关的并发症.
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