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在交细胞学的解释方面,观察者之间达成一致
Maria Benevolo1, Francesca Rollo1, Alessandra Latini2
1Pathology Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Cancer cytopathology
|March 7, 2024
概括
门细胞学显示,细胞病理学家在与男性发生性关系的HIV阴性男性 (MSM) 中进行门癌症查方面达成了很好的协议. 这种可复制性支持其在高风险人群中的使用.
科学领域:
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 门细胞学对于高危人群门癌症的查至关重要.
- 解释的可复制性对于准确的选至关重要.
- 这项研究评估了门细胞学中观察者之间的一致性.
研究的目的:
- 为了评估两个细胞病理学家解释门细胞学幻灯片之间的协议.
- 为了确定门细胞学用于门癌症查的可重复性.
- 评估人类乳头瘤病毒 (HPV) 对解释协议的影响.
主要方法:
- 两位专家细胞病理学家审查了来自HIV阴性MSM的基于液体的门细胞学幻灯片.
- 不一致的案件被审查以达成共识.
- 进行了人类乳头瘤病毒 (HPV) 基因型鉴定.
- 科恩·卡帕的统计数据是用来衡量协议的.
主要成果:
- 两位读者之间的总体一致率为92.1% (kappa = 0.85).
- 不同的解释显示了93.3%的同意 (kappa = 0.82).
- 对消极病例 (96.8%) 的同意率最高,对非典型状细胞 (76.9%) 的同意率最低.
- 不一致的解释与HPV状态或年龄无关.
结论:
- 在门细胞学解释中,观察者之间有很好的一致性.
- 这些发现支持可靠地使用门细胞学来查HIV阴性MSM.
- 在这个人群中,可复制性被证实为门细胞学的强度.
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