含有益生菌的饮料和牙损伤:系统性审查和元分析
Alexandra Feldmann1, Gustavo Eidt1, Sandra Liana Henz1
1Preventive and Community Dentistry Department, Dental School, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
European journal of oral sciences
|March 7, 2024
概括
含有益生菌的饮料对牙损产生了不一致的影响. 虽然它们没有显著减少化病变,但它们确实减少了儿童和青少年化和非化病变的增加.
科学领域:
- 口腔健康 口腔健康
- 微生物学 微生物学
- 预防性牙科 预防性牙科
背景情况:
- 牙损仍然是一个重要的全球健康问题.
- 益生菌通过调节口腔微生物组,为空预防提供了潜在的途径.
- 关于含有益生菌的饮料在治疗牙损伤方面的疗效的证据需要系统评估.
研究的目的:
- 系统地审查和元分析随机的安慰剂对照试验,研究含有益生菌的饮料对牙损伤的发展的影响.
- 评估对不同年龄组的皮肤损伤患病率和皮肤损伤增加的影响.
主要方法:
- 在2023年10月之前进行全面的数据库搜索 (PubMed,Embase,Web of Science).
- 包括随机的安慰剂对照试验,以牙损伤作为主要终点.
- 使用Cochrane手册和提取数据的元分析进行偏差风险评估.
主要成果:
- 对9项研究 (超过2000名参与者) 的定性分析显示,含益生菌饮料的效果不一致.
- 超过1000名儿童和青少年的元分析显示,化病变流行率没有显著差异 (RR 0.60 [95% CI 0.34-1.08]).
- 观察到化和非化病变的增加显著减少 (SMD -0.23 [95% CI -0.39至 -0.08]).
结论:
- 目前的证据不足以强烈支持含有益生菌的饮料对的整体发展的影响.
- 关于脏病发病率的证据存在中等确定性,而关于脏病增加的证据较低.
- 需要进一步进行高质量的研究,以澄清这些饮料在空预防策略中的作用.
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