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奥斯塔林减弱了耐力训练对大鼠次最大耐力的影响

Veselin Vasilev¹, Nikolay Boyadjiev², Petar Hrischev²

¹Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, 15-A "Vasil Aprilov" Blvd, Plovdiv, 4002, Bulgaria. v_vasilev1892@abv.bg.

Naunyn-Schmiedeberg's archives of pharmacology

|March 7, 2024

概括

奥斯塔林是一种SARM,在老鼠中降低了耐力和增加了肌静止素基因表达,但没有影响最大性能或荷尔蒙. 耐力训练提高了亚最大和最大的运动能力.

科学领域:

运动生理学运动生理学
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

选择性雄激素受体调节剂 (SARMs) 正在研究潜在的治疗益处.
了解像奥斯塔林这样的SARM对运动表现和肌肉适应的影响至关重要.

研究的目的:

研究奥斯塔林单独和耐力训练对雄性Wistar大鼠的影响.
评估功能性,荷尔蒙性,人体测量性和肌性基因表达变化.

主要方法:

成年雄性Wistar大鼠被分为久坐和跑步机训练小组.
鼠类接受了奥斯塔林或载体的治疗,持续了8周.
评估了耐力,握力,激素水平和基因表达 (myostatin,IGF-1,VEGF-A).

主要成果:

奥斯塔林降低了亚最大耐力,并增加了肌静止素基因表达.
训练增强了次最大和最大的耐力和握力.
无论是奥斯塔林还是训练都没有显著改变最大耗尽时间,激素水平或IGF-1/VEGF-A表达.

结论:

奥斯塔林可以增加肌静止素基因表达,而不会影响人类测量或荷尔蒙参数.
SARM治疗对亚最大耐力有负面影响,但对最大容量没有影响.
耐力训练提高了亚最大和最大的运动性能.

关键词:

耐力耐力耐力耐力奥斯塔林 (Ostarine) 是一种奥斯塔林类药物.这就是SARMs的意义.在最大限度以下的训练.测试激素测试激素是什么

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