在印度的mithun (Bos frontalis) 发现结块性皮肤病的第一个证据
Gundallahalli Bayyappa Manjunatha Reddy1, Pabbineedi Sai Mounica2, Nagaraj Sudeep2
1ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru, 560064, India. gbm.reddy@icar.gov.in.
Archives of virology
|March 7, 2024
概括
结节性皮肤病 (LSD) 首次在印度的mithun (Bos frontalis) 中得到证实. 遗传分析显示,相同的LSD病毒菌株在米和牛中循环,这表明潜在的物种溢出.
科学领域:
- 兽医病毒学 兽医病毒学
- 传染性疾病 传染性疾病
- 牛的健康问题
背景情况:
- 结节性皮肤病 (LSD) 主要影响牛,可能导致水牛的轻微感染.
- 之前没有关于mithun (Bos frontalis) 中LSD的报道,尽管它们在印度东北部和周边地区存在.
- 了解LSD的宿主范围对于疾病管理和预防至关重要.
研究的目的:
- 在印度的mithun (Bos frontalis) 报告Lumpy皮肤病 (LSD) 的第一次发生.
- 用病毒学和血清学方法确认诊断.
- 为了调查mithun中的LSD病毒与牛中发现的LSD病毒的遗传关系.
主要方法:
- 临床观察和典型的LSD标志的记录在受影响的mithun.
- 通过聚合酶链反应 (PCR) 放大病毒的隔离和鉴定.
- 关键病毒基因 (RPO30和P32) 的序列分析.
- 使用间接酶相关免疫吸收试验 (ELISA) 和血清中和试验进行血清学确认.
主要成果:
- 在mithun.com观察到与LSD一致的典型临床症状.
- 在受影响的mithun群体中成功分离和鉴定了LSD病毒.
- 对RPO30和P32基因的遗传学分析显示,mithun和牛的LSD病毒之间100%的序列一致性.
- 在mithun血清中检测到LSD病毒的抗体.
结论:
- 这项研究证实了印度mithun的Lumpy皮肤病 (LSD) 的第一例记录.
- 遗传数据强烈表明,在米和牛群中,单一LSD病毒菌株的循环.
- 这些发现强调了mithun对LSD的敏感性以及印度物种间疾病传播的潜力.
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