较高的动脉硬度预测成人慢性病:ELSA-巴西队列研究
Júlia Cândido1, Lidyane do Valle Camelo1, Luisa Brant1
1Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.
Arquivos brasileiros de cardiologia
|March 7, 2024
概括
较高的动脉硬度,以心至股骨脉动波速 (cfPWV) 衡量,显著增加患慢性病 (CKD) 的风险. 这种关联在没有高血压和糖尿病的个体中尤为明显.
科学领域:
- 心血管健康 心血管健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 动脉硬化可以直接影响功能,因为高血流.
- 动脉硬与功能之间的关系,特别是关于糖尿病和高血压的关系,仍在争论中.
研究的目的:
- 调查动脉硬化 (cfPWV) 与慢性病 (CKD) 的发生率之间的联系.
- 为了确定这种联系是否在没有高血压和糖尿病的个体中持续存在.
主要方法:
- 这是一项长度研究,对来自ELSA-巴西队列的11,647名参与者进行了长达四年的研究.
- 基线cfPWV按性别特定的四分位数进行分类.
- 结核病被定义为eGFR<60ml/min/1.73m2和/或专与肌素的比率≥30mg/g.
- 使用了后勤回归模型,调整了多个共同变量.
主要成果:
- 在cfPWV最高四分之一的个体中,CKD的几率增加了42%.
- 在正常血压,非糖尿病参与者中,高cfPWV四分位数与增加的CKD风险有关,最高四分位数显示最大的几率 (OR:1.81).
结论:
- 增加的动脉硬度 (较高的cfPWV) 是CKD的重要预测因素.
- 动脉硬与CKD风险之间的关联在没有高血压和糖尿病的个体中被放大.
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