由于银纳米颗粒引起的Colossoma macropomum幼虫的血细胞变化
Juliana O Meneses1, Fernanda Dos Santos Cunha1, Joel Artur R Dias2
1Pós-Graduação em Saúde e Ambiente, Universidade Tiradentes, Avenida Murilo Dantas, 300, 49032-490 Aracaju, SE, Brazil.
Anais da Academia Brasileira de Ciencias
|March 7, 2024
概括
银纳米粒子 (AgNP-PVA) 对tambaqui鱼具有高度毒性,其致命度为165.09μg/L. 虽然高度会引起呼吸道毒性,但鱼类可以适应低于125μg/L的较低水平.
科学领域:
- 环境毒理学环境毒理学
- 水生毒理学 水生毒理学
- 纳米毒理学研究
背景情况:
- 银纳米粒子 (AgNP-PVA) 的使用越来越多,引发了人们对其环境影响的担忧.
- 水生生物,特别是鱼类,对纳米粒子暴露很脆弱.
- 了解银纳米颗粒的毒性对于水生生态系统的风险评估至关重要.
研究的目的:
- 为了确定tambaqui鱼 (Colossoma macropomum) 中银纳米颗粒 (AgNP-PVA) 的中位致命度 (LC50).
- 评估AgNP-PVA暴露对tambaqui的血液参数的影响.
- 评估鱼类对不同度的AgNP-PVA的适应能力.
主要方法:
- 用六种不同的AgNP-PVA度进行急性毒性测定.
- 使用探针回归估计LC50.
- 使用T测试和图基测试分析血液参数 (葡萄糖,血红素,血蛋白,血红蛋白,血细胞).
主要成果:
- 估计的LC50为165.09μg/L,表明对tambaqui的高毒性.
- 死亡的鱼类显示葡萄糖,血红素,血蛋白,血红素,红细胞,白细胞,单细胞和中性粒细胞增加,MCV减少.
- 鱼类在187.5μg/L的暴露中存活下来,血红素,MCV,MCH变化,红细胞和白细胞减少. 暴露于<125μg/L的鱼类显示出血液参数的恢复.
结论:
- 银纳米粒子 (AgNP-PVA) 对tambaqui鱼具有高急性毒性,血液参数发生显著变化.
- 低于125μg/L的度允许适应,而更高的度会导致毒性和死亡.
- 该研究强调,需要在水生环境中谨慎管理AgNP-PVA,以保护鱼群.
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