中的表观遗传变化是由温度产生的,并通过RNA的介导传递给许多后代
Jaroslav Pavelka1, Simona Poláková2, Věra Pavelková3
1University of West Bohemia, Centre of Biology, Pilsen, Czech Republic.
PloS one
|March 7, 2024
概括
面粉的表观遗传变化可以持续40代,通过小RNAs传播,抑制突变并恢复野生表型. 这种跨代表观遗传效应突出显示了RNA.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 在性繁殖动物中,表观遗传变化通常是短暂的.
- 面粉 (Ephestia kuehniella) 的短天线 (sa) 突变是一个独特的案例研究.
研究的目的:
- 为了研究面粉持续40代的表观遗传现象.
- 确定这种扩展的跨代表观遗传效应的分子机制和原因.
主要方法:
- 通过环境因素 (温度,食物,盐) 和RNA注射诱导表观遗传变化.
- 对表观遗传效应跨代的持久性和传播的观察.
- 分析小RNAs (piRNA,miRNA,tsRNA) 在表观遗传中的作用.
主要成果:
- 一个表观遗传变化抑制了这种突变,并恢复了一个野生的表型被观察到40代.
- 这种效应很可能是由通过性子细胞传递的小RNA介导的.
- 环境因素和RNA注射可以诱导这种跨代表观遗传抑制.
结论:
- 小RNA介导的表观遗传可以在Ephestia kuehniella中持续40代,这是前所未有的.
- 这种可能与环境适应相关的现象可能会对进化产生重大影响.
- 这项研究表明,与SIR2基因存在潜在的联系.
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