对于中枢神经系统感染的Ceftaroline:一个年幼婴儿的病例报告,以及范围审查
Haley Urbach1, Nicole Sileo2, Sergio Lerma3
1From the Department of Pediatrics, Yale New Haven Children's Hospital, New Haven, Connecticut.
The Pediatric infectious disease journal
|March 7, 2024
概括
塞法托林在治疗中枢神经系统 (CNS) 感染方面表现有前途,特别是在儿童中,具有罕见的副作用. 需要更多的真实数据来确认其在中枢神经系统感染的儿科患者的疗效和安全性.
科学领域:
- 传染性疾病 传染性疾病
- 儿科神经学 儿科神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于抗生素的副作用和中枢神经系统 (CNS) 透率差,对儿童的内感染的管理具有挑战性.
- 塞法托林具有良好的安全性和抗耐药细菌的活性,但对中枢神经系统感染的数据有限.
研究的目的:
- 评估塞法托林在治疗中枢神经系统 (CNS) 感染方面的疗效和安全性.
- 对儿童和成人中枢神经系统感染中使用塞法托林的现有文献进行审查.
主要方法:
- 一个病例报告显示,一个2个月大的婴儿成功地用Ceftaroline,Vancomycin和Rifampin治疗了关节关联的腹腔炎.
- 来自PubMed,EMBASE和Web of Science的英语文献对中枢神经系统感染的Ceftaroline进行了范围审查.
主要成果:
- 该综述确定了92名患者,其中2名年龄在21岁以下,接受了中枢神经系统感染的Ceftaroline治疗,通常是组合治疗.
- 大多数病例报告表明临床成功,而小型研究显示出不同的结果. 副作用很少见,包括可逆性骨髓抑制.
- 药物动力学数据表明,与其他β-乳酸抗生素相比,中枢神经系统的透程度相当.
结论:
- 证据支持使用Ceftaroline与其他药物治疗中枢神经系统感染.
- 为了确定Ceftaroline在儿科和成人中枢神经系统感染中的疗效和安全性,特别是在没有临床试验的情况下,额外的现实世界的数据至关重要.
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