放射性治疗是否会损害眼系统?
1From the Ophthalmology Clinic, Beyoglu Eye Training and Research Hospital, Health of Sciences University.
Clinical nuclear medicine
|March 7, 2024
概括
放射性 (RAI) 治疗甲状腺功能升高和甲状腺癌可能会影响功能. 高剂量的RAI显著降低了患者的眼分泌和增加了眼度,效果在六个月后正常化.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 核医学是一种核医学.
背景情况:
- 放射性 (RAI) 治疗是甲状腺功能障碍和甲状腺癌的标准治疗方法.
- 在RAI治疗后,有事报告眼部副作用,包括眼睛干燥.
- 在RAI后对眼腺功能进行定量评估对于了解与治疗相关的眼部发病率至关重要.
研究的目的:
- 在患有甲状腺功能过高和甲状腺癌的患者接受放射性 (RAI) 治疗之前和之后量化评估眼腺功能.
- 为了评估不同RAI剂量对膜参数的影响.
主要方法:
- 涉及40名患者 (80只眼睛) 的前性研究,分为甲状腺功能增高 (低剂量RAI) 和甲状腺癌 (高剂量RAI) 组.
- 眼科检查,希尔默测试,撕裂时间 (TBUT),撕裂度 (TO) 和眼睛表面检查在RAI之前进行,并在RAI后1个月和6个月进行.
- 低剂量和高剂量RAI组之间的功能参数的比较.
主要成果:
- 在低剂量RAI组 (甲状腺过高) 中,没有观察到眼膜测试的显著变化.
- 高剂量RAI (甲状腺癌) 组在治疗后1个月显示了席尔默和TBUT值的显著下降以及TO的显著增加.
- 高剂量组的这些功能变化在6个月的随访后正常化.
- 在高剂量组1个月后,10%的患者表现出Schirmer分数<10毫米,TBUT<10秒,TO>308mOsm/L.
结论:
- 低剂量RAI治疗甲状腺功能障碍的治疗没有显著改变功能测试.
- 对甲状腺癌的高剂量RAI治疗导致眼分泌暂时减少,并在治疗后的早期增加眼度.
- 这些发现突出了RAI对眼腺功能的剂量依赖作用,强调了需要监测接受更高剂量的患者的眼皮表面健康.
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