在患者中,药物治疗问题和促成因素
Yirga Legesse Niriayo1, Tesfay Gebregziabher1, Gebre Teklemariam Demoz2
1Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, Ethiopia.
PloS one
|March 7, 2024
概括
药物治疗问题在患者中很常见,影响了超过一半的研究对象. 组合治疗和不受控制的发作显著增加了这些问题的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 神经学 神经学
背景情况:
- 抗发作药物对于管理至关重要,但可能导致与药物有关的问题.
- 这些问题损害了控制,降低了生活质量,增加了死亡率.
- 关于患者药物治疗问题及其原因的数据有限.
研究的目的:
- 为了确定患者药物治疗问题的患病率.
- 确定导致该人口中药物治疗问题的因素.
主要方法:
- 在埃塞俄比亚进行了一项基于医院的前性观察性研究.
- 包括成人患者在抗发作药物治疗≥6个月.
- 数据收集涉及患者采访和医疗记录审查,并使用Cipolle的方法对问题进行分类.
主要成果:
- 在250名患者中,有55.2%的患者经历了药物治疗问题,总共有282个问题.
- 常见的问题包括剂量过低 (30%),不遵守规则 (22%),药物不良反应 (18%).
- 芬尼托因,瓦尔酸和芬诺巴比他 (Phenobarbital) 经常受到影响.
结论:
- 药物治疗问题在患者中很普遍.
- 组合疗法和不受控制的发作是显著的危险因素.
- 建议针对多种药物和不受控制的发作患者进行有针对性的干预.
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