大脑干控制发声及其与呼吸的协调
Jaehong Park1,2, Seonmi Choi1, Jun Takatoh1
1Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
概括
研究人员在反复模糊核 (RAmVOC) 中发现了控制声带关闭和小鼠超声波发声的特定神经元. 这些RAmVOC神经元与呼吸协调发声,
科学领域:
- 神经科学
- 语音研究
- 呼吸系统的控制
背景情况:
- 需要精确的喉肌肉控制与呼吸协调.
- 声喉呼吸协调的神经机制尚未完全理解.
研究的目的:
- 在小鼠中识别控制声带引和超声波发声的神经回路.
- 调查反复模糊核 (RAmVOC) 神经元在声音产生和呼吸协调中的作用.
主要方法:
- 在小鼠的反复模糊核 (RAmVOC) 中识别发声特异性前运动神经元.
- 对RAmVOC神经元活动和抑制突触的实验性操纵.
- 分析发声模式和呼吸阶段协调.
主要成果:
- RAmVOC神经元对于声带关闭和USV产生是必要和足够的.
- RAmVOC激活时间影响USV音节长度和过期.
- 在吸气过程中,从前Bötzinger复合体门中抑制RAmVOC活动,确保声呼吸协调.
结论:
- 反复模糊的核中包含激发前运动神经元, 对于发声至关重要.
- 一个涉及RAm和VOC的神经电路及其抑制输入控制声呼吸协调.
- 阻断性关门的破坏导致发声和呼吸之间的失调.
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