观察者间和观察者内部的可靠性和O2Pulse在心肺运动测试中的屈曲的一致性:主观和新型客观方法的比较
Thomas Nickolay1,2, Gordon McGregor3,4,5, Richard Powell3,4
1Hull York Medical School, University of Hull, Hull, United Kingdom.
PloS one
|March 7, 2024
概括
这项研究验证了在心肺运动测试 (CPET) 期间识别氧脉冲 (O2Pulse) 屈曲的客观算法. 该算法显示出高可靠性,为评估功能能力提供了对主观解释的一致替代方案.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 生物医学工程 生物医学工程
背景情况:
- 心肺运动测试 (CPET) 是功能能力评估的黄金标准.
- 氧气脉冲 (O2Pulse) 曲率是心肌缺血的潜在指标.
- 确定O2Pulse曲线的可靠性需要进行彻底的调查.
研究的目的:
- 评估在CPET期间主观O2Pulse屈曲识别的观察者间和观察者内部可靠性.
- 提出和评估一种新的客观算法,用于O2Pulse屈曲量化.
- 为了比较主观与客观方法的可靠性.
主要方法:
- 从HIIT或MISS英国试验的基线数据的回顾性分析.
- 由两个独立检查员对O2Pulse曲线进行视觉检查.
- 与一个新的客观量化算法进行比较;用于可靠性分析的Fleiss' Kappa和ICC.
主要成果:
- 客观算法和审查者之间几乎完全一致 (Fleiss' Kappa = 0.89).
- 该算法的评级者之间的可靠性非常好 (ICC: 0.92-0.98).
- 在布兰德-阿尔特曼分析中,新手检查员发现了显著的系统偏差.
结论:
- 主观和新型客观方法都可靠地在CPET期间识别O2Pulse曲线.
- 客观算法显示出高可靠性和一致性.
- 对临床意义的进一步研究是有必要的;客观的量化确保了公平的患者结果.
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