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Updated: Jun 20, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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多个遗传位置影响了在基因多样化的小鼠中疫苗诱导的对Mycobacterium结核病的保护

Sherry L Kurtz1, Richard E Baker2, Frederick J Boehm3

  • 1Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America.

PLoS pathogens
|March 7, 2024
PubMed
概括

宿主遗传学影响BCG疫苗对结核病的有效性. 这项研究确定了控制免疫反应的遗传位置,揭示了保护是对新疫苗开发至关重要的多基因特征.

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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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