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Updated: Jul 1, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

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WSB1/2向染色体结合的氨酸甲基化RelA用于蛋白质体降解和NF-κB终结

Jie Zhang1, Yuanyuan Yu2,3, Xiuqun Zou1

  • 1Hongqiao Institute of Medicine, Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Nucleic acids research
|March 7, 2024
PubMed
概括

WSB1 和 WSB2 E3 酶向甲基化RelA进行蛋白质体降解,终止促炎性基因转录. 这一发现为NF-κB信号介导的炎症性疾病提供了新的治疗点.

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