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Updated: Jul 1, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

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在活细胞中使用人工G4向生物酶识别G-四重复相互作用蛋白

Ziang Lu1, Shengjie Xie1, Haomiao Su2

  • 1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.

Nucleic acids research
|March 7, 2024
PubMed
概括

研究人员开发了G4PID,该工具用于识别与G四重复合体 (G4s) 相互作用的蛋白质. 这种方法揭示了149种潜在的G4结合蛋白,包括SF3B4,它通过G4结构调节mRNA拼接.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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