一个时代的进步系统疗法用于高级甲状腺癌的时代
1Division of Hematology-Oncology, Moores Cancer Center at UC San Diego Health, La Jolla, CA.
JCO oncology practice
|March 7, 2024
概括
包括口服激酶抑制剂在内的向疗法正在彻底改变甲状腺癌治疗. 这些进展为患有晚期或转移性甲状腺癌的患者提供了新的希望,改善了治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺癌有各种各样的亚型,但分子理解已经重塑了治疗.
- 针对性疗法现在对于管理渐进的,放射性 (RAI) 耐火的分化甲状腺癌 (DTCs) 和髓性甲状腺癌 (MTCs) 至关重要.
研究的目的:
- 审查转移性甲状腺癌治疗的最新进展.
- 专注于系统疗法,改变高级甲状腺癌的管理.
主要方法:
- 关于甲状腺癌分子瘤发生和向治疗的当前文献的综述.
- 对已批准的口服激酶抑制剂及其在特定甲状腺癌亚型中的有效性进行分析.
主要成果:
- 口服激酶抑制剂,如索拉费尼布,伦瓦提尼布,卡博赞提尼布和万德坦提尼布是转移性RAI耐火DTC和MTC的标准治疗方法.
- 向疗法对BRAF,RET,NTRK,ALK和ROS1的突变,甚至在厌塑性甲状腺癌中都显示出有效性.
结论:
- 基因分析是个性化甲状腺癌护理的重要组成部分.
- 系统疗法显著提升了转移性和晚期甲状腺癌的治疗环境.
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