将思丁与Pinellia pedatisecta Schott脂溶性提取物结合使用,可诱导宫癌中瘤免疫细胞死亡

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Congwen Wang¹, Mingxing Zhang¹, Jing Peng¹

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Phytomedicine : international journal of phytotherapy and phytopharmacology

|March 7, 2024

概括

皮内利亚小虫 (Pinellia pedatisecta Schott) 提取物 (PE) 通过通过ER应激和ROS信号传递诱导免疫细胞死亡 (ICD) 来恢复西斯普拉丁的免疫性. 这种协同方法通过将垂死的瘤细胞转化为疫苗来增强癌症治疗.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

皮内利亚小 (Pinellia pedatisecta Schott) 提取物 (PE) 是来自中国传统药用植物的提取物.
PE显示出直接抗癌作用和免疫系统激活的潜力.

研究的目的:

调查PE在重建西斯的免疫性 (CDDP) 中的机制.
探索PE如何增强对癌症的免疫反应.

主要方法:

用CDDP和/或PE治疗宫癌细胞.
评估卡尔雷蒂库林 (CRT) 暴露,细胞外ATP和HMGB1释放.
在体内评估免疫特征,并分析ROS/ERS通路.

主要成果:

在瘤细胞中,PE诱导CRT转位和免疫细胞死亡 (ICD).
PE的免疫性诱导是由ER压力激活的,并阻碍了抗氧化机制.
用PE治疗的垂死的瘤细胞起到了疫苗的作用,启动了免疫反应.

结论:

由PE诱导的CRT暴露补偿了CDDP缺乏免疫性,刺激了强大的ICD.
PE通过ROS诱导的ER压力恢复CDDP免疫性,涉及ATF3和IRE-1α等蛋白质.
PE和CDDP组合显示出增强宫癌治疗中的免疫化学疗法的前景.

关键词:

暴露于卡莱蒂库林的时间宫癌是发生在宫癌的原因之一.免疫化疗是一种免疫化学疗法.免疫原性细胞死亡皮内利亚小植物提取物提取物有反应性氧物种的反应性氧物种.

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