探索黄素在病影响的牙粘附中的作用:全面的范围审查
Camilla Karoline de Carvalho Beckman1, Tainá de Lima Costa2, Regina Maria Puppin-Rontani3
1Departamento de Ciências da Saúde e Odontologia Infantil, Área de Odontopediatria, Faculdade de Odontologia de Piracicaba (FOP) - Universidade Estadual de Campinas (UNICAMP), Piracicaba, SP, Brazil.
Archives of oral biology
|March 7, 2024
概括
黄胺增强牙结合,通过在牙损伤受影响的牙中保存原蛋白,并抑制矩阵金属蛋白酶 (MMP). 这种生物修饰改善了材料性能,并确保了更稳定的粘合剂恢复.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 生物化学 生物化学
背景情况:
- 牙损伤的牙由于原降解而对粘合性修复提出了挑战.
- 矩阵金属蛋白酶 (MMPs) 是关键的酶,负责牙中的原分解.
- 改善牙粘合剂的寿命和稳定性是一个重要的临床目标.
研究的目的:
- 对使用黄类药物治疗牙损伤的牙进行范围审查.
- 评估黄素对牙结合和原蛋白保存的影响.
- 综合了关于黄素在改变牙的生物和机械性质中的作用的证据.
主要方法:
- 在五个数据库 (PubMed,EMBASE,Scopus,Web of Science,Scielo) 进行全面的文献搜索,更新至2023年4月.
- 包括体外,现场和体内研究,不包括灰色文献和纯植物提取物.
- 从91个已识别的研究中选择了16个研究数据的叙述和描述性分析.
主要成果:
- 分析了八种黄类药物,它们被用作预处理或被纳入牙科材料中.
- 黄酸改善了牙科材料的机械性能.
- 黄类药物通过抑制MMPs的蛋白质分解活性来减少原蛋白的损失,从而改变牙基质原纤维.
结论:
- 黄类药物通过抑制MMPs来保护混合层中的原蛋白.
- 黄胺修改了牙基质的原纤维,增强了粘合系统的机械性能.
- 黄酸的应用显示出牙生物修饰的前景,导致粘合剂修复中更稳定的粘合.
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