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人类癌症中的卡德林-17 (CDH17) 表达:对18,131种瘤进行组织微阵列研究

Frank Jacobsen¹, Ramesh Pushpadevan¹, Florian Viehweger¹

¹Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Pathology, research and practice

|March 7, 2024

概括

卡德林-17 (CDH17) 是肠道细胞中发现的蛋白质,使其成为癌症治疗的潜在目标. 这项研究在许多癌症中绘制了CDH17表达的地图,揭示了其诊断潜力,特别是在区分胃肠和肺腺癌方面.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫组织化学免疫组织化学

背景情况:

卡德林-17 (CDH17) 是一种细胞粘附蛋白,主要在胃肠道表达.
它的受限表达模式表明,它有可能成为癌症的诊断和治疗目标.

研究的目的:

在广泛的人类瘤类型和正常组织中全面地绘制CDH17蛋白质表达.
评估CDH17免疫组织化学 (IHC) 在癌症中的诊断效用.

主要方法:

使用大规模组织微阵列 (TMA) 采集了来自150种瘤类型/亚型和76种正常组织类型的14948个样本.
进行免疫组织化学 (IHC) 检测和量化CDH17蛋白表达在膜状模式.

主要成果:

CDH17主要表达在正常的肠道和胰腺管道上皮质中.
在150种瘤类别中的53种瘤中观察到阳性,特别是结肠直肠瘤,胃肠腺癌,粘膜性卵巢癌和某些神经内分泌瘤.
肺腺癌呈现出较低的CDH17阳性 (9.9%).
在结直肠癌中,减少CDH17染色与晚期瘤阶段,结节转移和微卫星不稳定性相关.

结论:

CDH17表达在各种表皮和神经内分泌瘤中很常见,特别是那些来自胃肠道和胆胰腺的瘤.
CDH17 IHC对于区分转移性胃肠/胆腺腺癌 (通常是阳性) 和原发性肺腺癌 (主要是阴性) 是有价值的.
这些发现支持CDH17作为潜在的治疗标和诊断标记.

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