中枢神经系统炎症性脱髓化疾病中的发作
Özdem Ertürk Çetin1, İpek Güngör Doğan1, Ümit Zanapalioğlu1
1University of Health Sciences, Sancaktepe Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
Multiple sclerosis and related disorders
|March 7, 2024
概括
发作是中枢神经系统炎症性脱髓化疾病中重要的临床特征. 髓寡腺细胞糖蛋白抗体相关疾病 (MOGAD) 患者经历了状态,而多发性硬化症 (MS) 的预后是好的.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 中枢神经系统的炎症性脱髓化疾病,如多发性硬化症 (MS),神经炎症光学谱障碍 (NMOSD) 和髓寡细胞蛋白抗体相关疾病 (MOGAD) 可能与发作和有关.
- 发作和的临床表现在这些疾病中各不相同.
研究的目的:
- 为了描述发作和的临床特征,在一个脱髓化的患者群体中.
- 为了解MS,NMOSD和MOGAD中发作的发生做出贡献.
主要方法:
- 在2019年至2024年期间被诊断患有脱髓化疾病的患者的回顾性分析.
- 纳入标准:在诊断出脱髓化疾病之前,期间或之后至少有一次发作的患者.
主要成果:
- 在1735名多发性硬化患者中,2.3%的人经历了发作;1.7%的人有MS无法解释的发作. 二次进展性多发性硬化症 (SPMS) 与复发性缓解性多发性硬化症 (RRMS) 相比,显示了更长的MS-间隔和更多的复发,两者都有良好的预后.
- 在21名抗体阳性NMOSD患者中,没有人在随访期间发作.
- 56名MOGAD患者中有3人 (5.4%) 经历了发作,所有患者都呈现为状态.
结论:
- 发作是中枢神经系统炎症性脱髓化疾病中显著的,尽管很少见的临床特征.
- 在MS中发作的潜在机制尚不清楚,并且可能根据疾病过程而有所不同.
- 状态在MOGAD患者中很常见,突出了在更大的队列中进一步研究的需要,以确定发作特征.
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