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细胞分泌的蛋白质在细胞吸收过程中调解不同尺寸的二氧化纳米颗粒的相互作用

Bin Huang¹, Jia-Ming Li², Xiao-Mei Zang²

¹Jiangsu Open Laboratory of Major Scientific Instrument and Equipment, Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology, School of Environment, Nanjing Normal University, Nanjing 210023, PR China; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu Province 210023, PR China.

Journal of hazardous materials

|March 7, 2024

概括

由于聚合和蛋白质相互作用,肺细胞吸收的二氧化纳米粒子 (SiO2NP) 与NP度发生变化. 了解这些复杂的纳米粒子相互作用对于安全评估至关重要.

科学领域:

纳米技术纳米技术
生物材料科学生物材料科学
细胞生物学细胞生物学

背景情况:

纳米粒子 (NP) 暴露导致其沉积在人体内.
之前的研究集中在单个NP吸收上,不清楚共存NP之间的相互作用.

研究的目的:

在细胞吸收过程中研究不同尺寸的二氧化纳米粒子 (SiO2NP) 之间的相互作用.
确定共存的NP如何影响肺癌细胞彼此的吸收动态.

主要方法:

使用两种SiO2NP大小与不同的Cd同位素进行差异化.
分析了A549人类肺癌细胞的NP吸收.
研究了NP聚合,蛋白质冠状形成和细胞分泌蛋白质的蛋白质组学.

主要成果:

一个SiO2NP大小的摄入量因另一种大小的存在而受到度依赖的改变.
NP聚合和蛋白质冠状形成影响了NP细胞相互作用和吸收竞争.
蛋白质学揭示了对与NP的蛋白质相互作用的见解.

结论:

同时存在的NP表现出影响细胞吸收的复杂相互作用.
细胞分泌的蛋白质及其冠状形成在NP行为中起着重要作用.
考虑NP的物理化学性质和蛋白质相互作用对于生物应用和安全性评估至关重要.

关键词:

聚合是一种聚合.共同暴露是指共同暴露.纳米颗粒纳米颗粒蛋白质冠状病毒的冠状病毒在Uptake竞争中获得优势.

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