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Updated: Jul 1, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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对CTCF拓边界的剖析揭示了增强剂-基因调节的原理

Kyung Lock Kim1, Gilbert J Rahme1, Viraat Y Goel2

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA.

Molecular cell
|March 7, 2024
PubMed
概括

在胃肠道 stromal 瘤 (GIST) 中 CTCF 边界的破坏融合了拓关联域 (TAD),使增强器基因通信和纤维细胞生长因子 (FGF) 瘤基因诱导成为可能.

关键词:
ANO1 一个年轻人在CTCF绝缘器上通过DNA甲基化.在FGF3FGF3在FGF4的基础上.SDH 缺乏症是SDH的缺陷.在这种情况下,染色染色素加强监管 加强监管 加强监管胃肠道 stromal 瘤是什么基因组拓学的基因组.

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