在老鼠的肠神经系统的圣神经独立起源
Qi Yu1, Li Liu2, Mengjie Du3
1Department of Neurology of the Second Affiliated Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Zhejiang University School of Medicine, Hangzhou, China; MOE Frontier Science Center for Brain Research and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China; Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, China.
Gastroenterology
|March 7, 2024
概括
哺乳动物的肠道神经系统 (ENS) 完全来自阴道神经细胞 (vNCCs),而不是阴道神经细胞 (sNCCs). 这一发现对于理解和治疗诸如赫尔施普朗格之类的肠神经系统先天性疾病至关重要.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 肠道神经系统 (ENS) 对肠道功能和肠-大脑通信至关重要.
- 它的发展主要归因于神经细胞 (vNCCs),神经细胞 (sNCCs) 的潜在贡献.
- 在现场区分这些细胞群体已经阻碍了对先天性ENS疾病的理解.
研究的目的:
- 精确确定哺乳动物肠道神经系统的起源.
- 解决阴道和阴道神经细胞对ENS发育的贡献.
主要方法:
- 基因工程小鼠胚胎用于神经细胞 (NCC) 的比较血统追踪.
- 采用双血统追踪和3D骨盆和后肠的3D重建.
- 进行共同培养试验,以评估细胞迁移的特异性.
主要成果:
- 只有包括vNCC在内的全NCC为ENS做出了贡献;sNCC没有.
- 在骨盆和后肠周围组织中观察到神经神经细胞 (sNCC),这解释了先前的混乱.
- 培养实验显示,来自各种神经组织的非特异性迁移到后肠.
结论:
- 哺乳动物的内脏神经系统完全来自神经细胞 (vNCCs).
- 圣神经细胞 (sNCC) 不会对小鼠ENS做出贡献.
- 这些发现对理解和治疗先天性肠胃神经系统疾病,如赫施普朗格病,有重大意义.
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