人类免疫缺陷病毒阳性患者的整体关节整形术:对结果的系统性审查
Alexandra Baker Lutz1, Deepak V Patel2, Christopher Bibbo3
1Department of Orthopaedic Surgery, University of Maryland Medical Center, Baltimore, Maryland.
The Journal of arthroplasty
|March 7, 2024
概括
关节整形术 (THA) 对患有股骨头骨硬化的HIV阳性患者有效. 包括生存率,生活质量和并发症率在内的结果与艾滋病毒阴性患者相似.
科学领域:
- 整形外科手术 整形外科手术
- 传染病管理 传染病管理
- 患者研究成果研究结果
背景情况:
- 股骨头骨硬化在人类免疫缺陷病毒 (HIV) 阳性患者中很常见,通常需要全关节整形术 (THA).
- 评估HIV阳性个体的THA结果对于优化治疗策略至关重要.
研究的目的:
- 系统地审查和评估HIV阳性患者的THA后的生存率,患者报告的结果 (PROM),感染率,并发症和免疫能力 (CD4+计数和病毒载荷).
- 为了比较艾滋病毒阳性和艾滋病毒阴性患者队列之间的这些结果.
主要方法:
- 对10项涉及9534名艾滋病毒阳性患者的研究进行系统审查,遵循PRISMA指南.
- 使用科尔曼方法得分和基于证据的医学中心标准进行质量评估.
- 数据提取的重点是生存率,PROMs,感染率,并发症和CD4+计数/病毒载荷.
主要成果:
- 植入物存活率在95%至100%之间,哈里斯部得分在THA后显著改善.
- 在HIV阳性和HIV阴性患者中,术后感染率和PROMs是可比的.
- 并发症率与匹配的对照组相似,CD4+计数/病毒载量没有显著影响结果.
结论:
- 关节整形手术对于艾滋病毒阳性患者,特别是患有骨髓缩的患者来说,是一种安全有效的干预措施.
- 在这个人群中,THA导致了极好的植入物存活率和改善生活质量.
- 在HIV阳性患者中,THA后感染和并发症的风险较低.
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