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引起的毒性对炎症性细胞因子的影响

P Harshitha¹, Kalpita Bose¹, Herman Sunil Dsouza²

¹Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

|March 7, 2024

概括

暴露于会引起氧化应激,破坏细胞功能并损害免疫系统. 这种重金属污染物会影响免疫细胞,细胞因子代谢和炎症反应,导致各种健康问题.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
免疫学免疫学免疫学

背景情况:

(Pb2+) 是来自人为来源的广泛存在的环境污染物.
暴露于会给健康带来重大风险,尤其是儿童,并且与中毒 (毒) 有关.
氧化应激越来越被认为是毒性病理生理学的关键因素.

研究的目的:

阐明暴露诱导氧化应激的机制.
研究诱导的氧化应激对免疫系统的影响.
了解如何影响细胞结构,炎症途径和免疫细胞功能.

主要方法:

审查有关毒性和氧化应激现有的证据.
对暴露的细胞反应的分析,包括反应性氧物种 (ROS) 生产.
检查对脂质过氧化,炎症信号和细胞因子代谢的影响.

主要成果:

暴露于会产生活性氧物种 (ROS),导致氧化应激和破坏细胞组件,如脂.
氧化应激激活炎症信号通路,损害免疫防御,并可能导致炎症和自身免疫.
暴露于会改变关键细胞因子 (例如IL-2,TNF-α) 和炎症酶 (例如循环氧基因酶) 的代谢和表达.

结论:

诱导的氧化应激是导致中毒对免疫系统有害影响的主要机制.
暴露于会通过影响细胞完整性,炎症反应和细胞因子信号传递来破坏免疫平衡.
了解这些机制对于制定减轻对健康影响的策略至关重要,因为毒性受到暴露因素和宿主遗传学的影响.

关键词:

细胞因子 (cytokines) 是一种细胞因子.炎症炎症是一种炎症.毒性的毒性的毒性氧化应激是一种氧化应激.这就是ROSOS ROS.

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