中老年和老年人的草甘暴露,肌肉健康和功能限制
Sara Jauregui-Zunzunegui1, Fernando Rodríguez-Artalejo2, María Tellez-Plaza3
1Department of Preventive Medicine and Public Health, Hospital Universitario Nuestra Señora de Candelaria, Spain.
Environmental research
|March 7, 2024
概括
暴露于草甘与美国成年人的手握力降低和身体功能限制增加有关. 这项研究强调了这种常见除草剂对肌肉功能和衰老的潜在风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 草甘是世界上使用最广泛的除草剂.
- 之前的研究表明,草甘暴露会对肌肉生理学和力量产生负面影响.
- 流行病学研究表明草甘与影响肌肉功能的不良健康结果之间存在联系.
研究的目的:
- 调查草甘暴露与肌肉力量之间的关联.
- 检查美国人口中草甘暴露和身体功能限制之间的关系.
主要方法:
- 利用来自美国国民健康和营养检查调查 (NHANES) 的数据,对美国普通人口进行了调查 (n=2132).
- 使用离子染色学与双重质谱学测量尿液中的草甘酸度.
- 评估手握强度 (HGS) 和相对强度 (HGS/ALMBMI),将低强度定义为低于性别,年龄和种族特定平均值的1 SD. 身体功能限制也被记录下来.
主要成果:
- 草甘度的增加与主导手HGS (-0.55公斤) 和相对强度 (-0.90公斤/ALMBMI) 的下降有关.
- 较高的草甘水平与低HGS (OR=1.27),低相对HGS (OR=1.43) 的可能性增加相关,以及下/跪下 (OR=1.33),举起/携带 (OR=1.17),站立 (OR=1.21) 和爬楼梯 (OR=1.47) 的困难.
结论:
- 暴露于草甘可能是减少握力和身体功能受损的重要风险因素.
- 需要进一步的研究来了解草甘和其他环境污染物的对功能衰老的影响.
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