达成共识:对Fontan相关并发症的严重程度分级定义,以表征Fontan循环衰竭
Kurt R Schumacher1, Ari Cedars2, Kiona Allen3
1Congenital Heart Center, C.S. Mott Children's Hospital, University of Michigan, Detroit, MI.
Journal of cardiac failure
|March 7, 2024
概括
专家们为Fontan并发症制定了严重程度分级的定义. 这些标准化定义将改善Fontan生理学幸存者的研究和患者结果.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 丰田生理学导致慢性器官变化,影响生存和心脏移植的成功.
- 缺乏对Fontan并发症的标准化定义,阻碍了对其对患者结果的影响的理解.
研究的目的:
- 制定基于共识的,严重程度分级的定义,对Fontan特有的心脏和心脏外并发症.
- 建立一个标准化的框架来评估Fontan患者的发病率.
主要方法:
- 一个由多学科专家组成的小组召开会议,使用严重程度分级的顺序表表 (等级1-4级) 创建定义.
- 第二个专家小组使用了经过修改的Delphi方法来完善和达成对定义的共识.
- 在三轮投票和修改后,在所有定义的并发症上达成共识 (>90%的协议).
主要成果:
- 对于众多的Fontan并发症,包括解剖阻塞,阴光症,心律失常,排泄,,失去蛋白质的肠病,塑性支气管炎,肝脏疾病,损伤和神经发育障碍等,达到了共识的定义.
- 开发的定义涵盖了与Fontan生理学相关的心脏和心脏外疾病的广泛范围.
结论:
- 已经成功地建立了对Fontan并发症的共识和严重程度定义.
- 这些定义为未来的研究提供了标准化工具,并改善了对Fontan患者结果的分析.
相关概念视频
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Heart Failure Drugs: Diuretics
375
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
375
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Disorders of the Autonomic Nervous System
637
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
637


