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微生物意米达 propionate 通过与 HSP90α 的关联,影响糖尿病脏病患者的淋巴膜过率

Dan Lv¹, Wenhan Zheng², Zheng Zhang²

¹Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Department of Neuroscience Research Center, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.

Biochimica et biophysica acta. Molecular cell research

|March 7, 2024

概括

肠道细菌代谢物伊米达 propionate (ImP) 在糖尿病病 (DN) 中升高. 通过促进纤维化和向HSP90,ImP会恶化损伤,这表明它有可能成为DN的诊断标记物和治疗点.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
代谢学代谢学代谢学
分子生物学分子生物学

背景情况:

伊米达 propionate (ImP) 是一种由肠道菌群从histidine产生的代谢物.
糖尿病病 (DN) 是糖尿病的严重并发症,其特征是损伤.

研究的目的:

调查ImP在糖尿病病 (DN) 中的作用.
确定ImP作为DN的潜在生物标志物和治疗点.

主要方法:

在DN患者中进行非向性血代谢分析.
用RNA测序 (RNA-seq) 来评估ImP对小鼠模型中的转录组的影响.
药物亲和反应目标稳定性 (DARTS) 试验,以确定ImP的分子标.

主要成果:

在DN患者中,ImP水平显著增加,与肌素和白色素尿相对应,与膜过率相对应.
在DN的小鼠模型中,ImP加剧了损伤,并促进了管上皮质-介质细胞过渡 (EMT).
ImP直接准HSP90α,激活EMT所涉及的PI3K-Akt信号通路.

结论:

通过诱导纤维化和EMT,ImP在DN进展中起着有害的作用.
ImP作为DN诊断的潜在生物标志物和新的治疗点.

关键词:

糖尿病脏病糖尿病脏病在EMT中,EMT是EMT.纤维化纤维化纤维化肠道微生物群的代谢物.伊米达 propionate 的使用方法

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