颗粒物沉积及其对结核病严重程度的影响:台北的一项横截面研究
Firdian Makrufardi1, Hsiao-Chi Chuang2, Chi-Won Suk3
1International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia.
The Science of the total environment
|March 7, 2024
概括
细颗粒物 (PM2.5) 暴露与结核患者胸部X射线异常增加有关. 空气污染可能会加剧放射性严重性和耐治疗性,特别是在多耐药结核病 (MDR-TB) 中.
科学领域:
- 环境健康 环境健康
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
背景情况:
- 颗粒物 (PM2.5) 是一种具有已知的呼吸系统影响的重要空气污染物.
- 结核病 (TB),包括多药耐药结核病 (MDR-TB),仍然是一个全球卫生挑战.
- PM2.5沉积对结核病患者肺部异常的具体影响需要进一步调查.
研究的目的:
- 调查吸入PM2.5的肺叶沉积剂量与胸部X射线异常之间的关联.
- 为了区分肺结核 (TB),多耐药结核 (MDR-TB) 和非结核菌菌 (NTM) 感染之间的这些关联.
- 探索环境和沉积的PM2.5和不同肺叶的放射性严重性之间的关系.
主要方法:
- 一项涉及台湾台北市1073名患者 (2014-2022) 的横截面研究.
- 对每个受试者的不同肺叶中环境和沉积的PM2.5的估计.
- 对年龄,性别,BMI,吸烟状况和家庭收入进行调整的回归分析,以导出β系数.
主要成果:
- 环境PM2.5增加1μg/m3与MDR-TB感染增加0.004倍有关.
- 在特定的肺叶中增加PM2.5沉积与结核病患者胸部X射线异常的百分比较高相关.
- 在膜区域的PM2.5沉积与MDR-TB患者的特定叶片异常增加有关.
结论:
- 吸入PM2.5沉积与肺结核的放射性严重性加剧有关,特别是在MDR-TB.
- 空气中的颗粒物污染可能会恶化放射性检测结果,并导致肺结核的耐治疗性.
- 调查结果突出了空气质量对结核病管理和结果的潜在公共卫生影响.
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