粮食不安全是拉丁裔儿童代谢功能障碍相关脂肪性肝病的危险因素
Sarah L Maxwell1, Jennifer C Price2, Emily R Perito1,3
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Pediatric obesity
|March 7, 2024
概括
儿童早期家庭的粮食不安全性显著增加了患儿代谢功能障碍相关脂肪性肝病 (MASLD) 的风险. 这项研究强调了粮食不安全和拉丁美洲儿童的MASLD之间的关键联系.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 公共卫生 营养 公共卫生 营养
- 儿童肥胖症 儿童肥胖症
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是美国儿童日益关注的问题.
- 现有的研究将粮食不安全与成年人中的MASLD联系起来,但儿科数据有限,特别是在高危人群中.
研究的目的:
- 研究4岁家庭粮食不安全与拉丁美洲儿童儿科MASLD发展之间的关联.
- 评估早期粮食不安全对儿童晚期MASLD风险的影响.
主要方法:
- 拉丁裔母亲及其子女的前性队列研究.
- 在4岁时使用美国家庭粮食安全食品模块评估家庭粮食不安全.
- MASLD定义为5-12岁之间氨酸转氨酶 (ALT) 和体重指数 (BMI) 的升高;使用多变量逻辑回归分析.
主要成果:
- 28.7%的儿童在4岁时经历了家庭粮食不安全; 27.2%的儿童患有MASLD.
- 患有MASLD的儿童更有可能出现粮食不安全 (49%对21%).
- 4岁时的粮食不安全独立预测了儿童晚年患MASLD的几率增加3.7倍.
结论:
- 幼儿家庭的粮食不安全是患儿MASLD的重要危险因素.
- 需要进行进一步的研究,以了解减轻粮食不安全的机制和潜在益处,以及对MASLD风险的潜在益处.
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