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含有氧酸盐的牙膏对一些牙相关变量的影响:一项随机临床试验

Guglielmo Campus¹, Fabio Cocco², Richard Johannes Wierichs³

¹Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland; Department of Surgery, Microsurgery and Medicine Sciences, School of Dentistry, University of Sassari, Sassari, Italy; Department of Cariology, Saveetha Dental College and Hospitals, SIMATS, Chennai, India.

International dental journal

|March 7, 2024

概括

与传统的化牙膏相比,化替代酸 (HAF) 牙膏在学生中显著增加了最低pH值,并减少了空性细菌. 需要进一步的研究来证实它在预防病变方面的有效性.

科学领域:

口腔健康研究口腔健康研究
微生物学微生物学
牙科公共卫生牙科公共卫生

背景情况:

牙损仍然是一个重要的公共卫生问题,特别是在儿童中.
传统的化物牙膏是有效的,但正在探索新的药物.
化物替代的酸 (HAF) 牙膏为预防牙提供了潜在的替代方案.

研究的目的:

评估化物替代酸 (HAF) 牙膏在调节口腔微生物群和生物膜酸性方面对学龄儿童的疗效.
为了将HAF牙膏与传统的单酸化牙膏进行比较.
在24个月的时间内评估对脏病风险因素的影响.

主要方法:

一项为期24个月的随机临床试验,涉及610名4-7岁的学龄儿童.
他们用了四种牙膏:两个HAF (1000和1450 ppmF) 和两个单酸 (1000和1450 ppmF).
在糖挑战后对膜上方斑块和斑块pH值测量的微生物学分析在基线,1年和2年进行.

主要成果:

在所有组中都观察到最低pH值的统计显著增加,HAF组的增加最大.
主要的菌细菌,包括Streptococcus mutans,Streptococcus sobrinus,Lactobacillus casei和Lactobacillus fermentum,在HAF组中相比化物组显著较低 (P = .03).

结论:

这项研究提供了强有力的证据,表明HAF牙膏有可能调节口腔微生物群并降低酸性.
虽然HAF牙膏表现出良好的微生物和pH调节效应,但关于虫病变预防的确证据需要进一步调查.
HAF牙膏显示出作为替代或辅助传统化物牙膏用于虫管理的承诺.

关键词:

牙损伤导致牙损伤.孩子孩子孩子孩子化物的化物.纳米-氧亚帕提特是一种纳米-氧亚帕提特.随机的临床试验随机的临床试验牙膏是一种牙膏.

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