在的脏移植患者中从即时释放转换为延长释放的塔克罗利:一系列案例研究
Dorota Kamińska1, Roman Hożejowski2, Andrzej Chamienia3
1Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Transplantation proceedings
|March 7, 2024
概括
将移植患者从即释放式塔克罗利 (IR-TAC) 转换为延长释放式塔克罗利 (LCPT) 显著降低了和改善了日常功能. 这种震管理策略在12个月内通过较低剂量维持治疗药物水平.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 药理学 药理学是指药理学的学科.
背景情况:
- 是一个常见的副作用在接受脏移植治疗的塔克罗利莫斯治疗.
- 塔克罗利斯诱导的震往往与血中药物度达到峰值有关.
研究的目的:
- 评估从立即释放的塔克罗利木斯 (IR-TAC) 转换为延长释放配方 (LCPT) 治疗震的疗效.
- 评估移植患者对日常活动和功能的影响.
主要方法:
- 这项研究涉及18名接受脏移植的接受者,他们在IR-TAC上经历了震.
- 在12个月的评估中,使用了基本震评分尺度的日常生活活动 (ADL) 亚尺度.
- 监测了塔克罗利斯的最低度 (C0) 和估计的淋巴球过率 (eGFR).
主要成果:
- 转换为LCPT导致ADL得分的显著和持续改善,这表明对日常生活的影响减少了 (63%的改善在12个月,P<.001).
- 在保持稳定的低谷度的同时,LCPT允许每日塔克罗利莫斯剂量减少40%.
- 在12个月的随访期间,功能保持稳定.
结论:
- 转换为LCPT是一种有效的策略,可以缓解移植患者的震症状.
- 这种开关通过增强日常活动而改善患者的生活质量,而不会影响治疗药物水平或功能.
相关概念视频
01:20Desensitization and Tachyphylaxis
1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
01:11Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
61
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
61
01:28Drug Therapy
43
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
43
01:12Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
994
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
994
01:20Antiepileptic Drugs: Potassium Channel Activators
183
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
183