在老鼠中,社交缓冲通过催产素减少恐惧,从而触发中枢杏仁体神经元活动的持续变化
Chloe Hegoburu1, Yan Tang1, Ruifang Niu1
1Center for Psychiatric Neuroscience, CHUV, Prilly-Lausanne, Switzerland.
Nature communications
|March 7, 2024
概括
社会缓冲通过激活大脑中的催产素通路来减少恐惧. 这项研究揭示了伴侣的存在如何将神经反应从恐惧转移到杏仁体中的安全信号.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 社会神经科学是一种社会神经科学.
背景情况:
- 社会缓冲,通过伴侣的存在来减少恐惧,是众所周知的现象.
- 参与社会缓冲的精确神经机制和大脑区域仍然不完全理解.
研究的目的:
- 研究恐惧社会缓冲的神经机制.
- 为了检查催产素信号在下丘脑-中央杏仁体通路中的作用.
- 了解在社会缓冲过程中,恐惧如何在杏仁体中被编码和调节.
主要方法:
- 在雄性和雌性大鼠中听觉恐惧调节.
- 药物学,光遗传学和化学遗传学操纵.
- 单个单元记录在中央杏仁体使用optetrodes.
主要成果:
- 从下丘脑向中枢杏仁体传递的催产素信号调解了急性恐惧减轻和长期的社会缓冲.
- 中枢杏仁体中的恐惧编码神经元被社会缓冲和催产素预测所抑制.
- 独特的中央杏仁体神经元被伴侣的存在和催产素激活,将条件刺激反应从恐惧转变为安全.
结论:
- 对恐惧的社会缓冲包括催产素介导的恐惧编码神经元的抑制和中央杏仁体中特定"缓冲神经元"的激活.
- 这一过程有效地将受条件刺激的神经表现从"恐惧"切换为"安全".
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