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Updated: Jul 1, 2025

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
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对IL-11介导信号传递和人类IL6ST变体相关免疫缺陷的结构性见解

Scott Gardner1, Yibo Jin1, Paul K Fyfe2

  • 1Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, SW7 2AZ, UK.

Nature communications
|March 7, 2024
PubMed
概括

通过gp130.0.gp11传递介质蛋白-11 (IL-11) 和介质蛋白-6 (IL-6) 的信号. 这项研究揭示了gp130突变如何通过改变受体灵活性和几何学来损害信号传输,从而影响免疫反应.

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