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Updated: Jul 1, 2025

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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在增强剂中通过POU2AF2/C11orf53介导的SWI/SNF依赖的转录调节

Aileen Szczepanski1,2, Natsumi Tsuboyama1,2, Huijue Lyu1,2

  • 1Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Nature communications
|March 7, 2024
PubMed
概括

蛋白质POU2AF2调节基因表达,这对细胞的身份和活力至关重要. 它的破坏会影响染色质结构和细胞生长,为小细胞肺癌 (SCLC) 提供潜在的治疗点.

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