通过一个自下而上的中脑-脑下丘脑通路来控制食
Fernando M C V Reis1, Sandra Maesta-Pereira2, Matthias Ollivier3
1Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. freis@ucla.edu.
Nature communications
|March 7, 2024
概括
周水道灰色 (PAG) 中的GABAergic细胞驱动食物的寻找和消费. 激活这些细胞有助于寻找食物和进食,揭示了影响养行为的自下而上的途径.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 探索探索和寻找食物是关键的行为,但它们的潜在神经机制仍然不完全理解.
- 已知 GABAergic 输入到侧面和腹侧面的 periaqueductal 灰色 (l/vlPAG) 调节这些行为.
研究的目的:
- 剖析l/vlPAG内囊泡GABA载体 (vgat) -表达GABA基细胞在控制探索,食和养行为方面的特定作用.
主要方法:
- 使用小鼠模型来研究表达vgat的GABAergic l/vlPAG细胞的功能.
- 研究了这些细胞在调节食物寻找和消费方面的活动的必要性和充分性.
- 研究了l/vlPAG vgat细胞与其他大脑区域 (包括不确定区域) 的解剖联系.
- 评估了激活这些细胞对探索性食,强迫性饮食和防御行为的影响.
主要成果:
- 发现vgat l/vlPAG细胞编码了对食物的接近以及活猎物和非猎物物品的消费.
- 这些细胞的活性被证明是必要的,也是足够的,以启动导致消费的寻找食物的行为.
- 激活vgat l/vlPAG细胞诱导探索性食和强迫性饮食,而不会影响防御行为.
- 在l/vlPAG vgat细胞和参与养和探索的关键节点之间确定了双向的神经连接,特别是不确定区域.
- 从l/vlPAG vgat细胞到不确定的区域的投射被证明是双向控制食品导向的方法和消费.
结论:
- 周水管灰色 (PAG) 在调节寻找食物和消费行为方面发挥着关键作用.
- 这些发现突出了源自PAG的自下而上的途径,影响了勘探和食,补充了已知的自上而下的途径.
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