在前皮质中的编码合集的重新激活支持时间关联
Thays Brenner Santos1, Cesar Augusto de Oliveira Coelho2, Juliana Carlota Kramer-Soares3,4
1Departamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, São Paulo, 04023-062, Brazil. thays.brenner@unifesp.br.
概括
参与学习时间恐惧关联的前临界皮层 (PL) 神经元也支持长期记忆检索. 这些PL神经元对于初始学习和这些记忆的稳定回忆至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 记忆研究 记忆研究
背景情况:
- 恐惧调节强化突触连接以形成记忆录.
- 前皮质 (PL) 参与时间关联的短期记忆.
- 在长期记忆检索中PL神经元的作用仍然不清楚.
研究的目的:
- 调查PL神经元是否支持暂时恐惧调节中的短暂短期和稳定的长期记忆.
- 识别参与时间关联学习和检索的神经元组合.
主要方法:
- 使用5秒间隔的恐惧调节 (CFC-5s) 和上下文恐惧调节 (CFC).
- 在小鼠中使用强健活动标记 (RAM) 和在活跃种群中有针对性的重组 (TRAP2).
- 使用光遗传学来操纵PL神经元组合,并分析网络协同激活.
主要成果:
- 对PL组合的光遗传学操纵影响了CFC-5的检索,但没有影响CFC的检索.
- 记忆检索CFC-5s重新激活了PL,周围内皮层 (PER) 和底侧杏仁体中的神经元组合.
- 在CFC-5s内存网络中,杏仁体和PER的中心性和相互连接性增加了.
结论:
- 同样的PL神经元参与时间关联记忆的学习和稳定回忆.
- 在记忆形成和检索中,PL神经元在短暂的表现之外发挥着持续的作用.
- 这项研究阐明了支时间联想记忆的神经回路.
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