美国成年人的全身免疫炎症指数和高血压之间的关联来自NHANES 1999-2018年
Ying Chen1, Yanping Li2, Mengqiong Liu1
1Medical Laboratory Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570311, Hainan, China.
Scientific reports
|March 7, 2024
概括
系统性免疫-炎症指数 (SII) 显示了美国成年人与高血压风险的U形联系. 较高或较低的SII水平可能表明高血压风险增加,转折点为5.89.
科学领域:
- 心血管健康 心血管健康
- 炎症生物标志物 炎症生物标志物
- 公共卫生研究 公共卫生研究
背景情况:
- 高血压是一种与全身炎症相关的重大心血管疾病.
- 由血液细胞计数得出的全身免疫炎症指数 (SII) 是一种新的炎症标志物.
- 了解SII和高血压风险之间的关系对于早期检测和预防策略至关重要.
研究的目的:
- 调查系统性免疫-炎症指数 (SII) 与大量美国成年人群中高血压风险之间的关联.
- 探索非线性关系,并确定SII与高血压相关的潜在转折点.
- 检查影响SII和高血压联系的潜在子组相互作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (1999-2018) 的数据,其中包括44,070名美国成年人.
- 计算的SII是 (中性粒细胞数 *血小板数) /淋巴细胞数.
- 采用加权多变量后勤回归,平滑曲线拟合和两部分后勤回归来分析关联.
主要成果:
- 在Ln(SII) 和高血压风险之间观察到统计学上显著的U形关联.
- 最高四分之一的Ln(SII) 与12%的高血压风险增加有关 (OR:1.12;95% CI 1.01,1.24).
- 确定了5.89 (1000个细胞/μl) 的拐点,这表明在较低和较高的SII水平上都有风险.
结论:
- 系统性免疫-炎症指数 (SII) 水平升高与美国成年人高血压风险增加有关.
- 观察到的U形相关性表明,非常低的和非常高的SII可能与高血压有关.
- 需要进一步的前性研究来证实这些发现并阐明潜在的机制.
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