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Updated: Jul 1, 2025

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SARS-CoV-2 Omicron亚变体的受体结合域准Siglec-9,通过防止巨细胞灭菌,降低其免疫性

Xin He1, Xiantao Zhang1, Bolin Wu1

  • 1Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Nature immunology
|March 7, 2024
PubMed
概括

在Omicron尖端蛋白中的特定突变 (F375S) 通过恢复祖先序列,显著提高了疫苗免疫性. 这种修改改善了巨细胞的功能,并增强了针对SARS-CoV-2变种的疫苗反应.

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