结核病和间歇性肺病:系统性审查和元分析
概括
结核病 (TB) 影响了11%的间歇性肺部疾病 (ILD) 患者. 病患者和来自高结核病负担的国家患者的风险更高,为查和治疗决策提供了信息.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 间歇性肺部疾病 (ILDs) 涵盖了一组异质的肺部疾病.
- 结核病 (TB) 是一个重要的全球健康问题.
- 在ILD患者中结核病的同时发生和患病率需要进一步调查.
研究的目的:
- 确定在被诊断为ILDs的患者中结核病的总体患病率.
- 为了比较不同ILD亚型之间的结核病患病率,特别是病和异常性肺纤维化 (IPF).
- 评估地理结核病负担对ILD患者结核病发病率的影响.
主要方法:
- 在PubMed/Medline,EMBASE和Scopus数据库中进行了系统的文献搜索.
- 包括到2023年8月1日发表的研究,报告了ILD患者的结核病患病率.
- 对12项涉及3817名患者的研究数据进行了元分析.
主要成果:
- 在所有ILD患者中结核病的综合流行率为11.0% (95% CI 5.4-21.0).
- 与IPF (4.4%) (P = 0.00) 相比,结核病发病率在症中显著更高 (35.6%).
- 在高结核病负担国家 (26.3%) 的患病率明显高于低/中等负担国家 (4.9%) (P = 0.00).
结论:
- 这一元分析量化了ILD患者结核病的频率.
- 病和高结核病负担区域与ILD患者的结核病风险显著增加有关.
- 这些发现有助于临床医生和政策制定者优化ILD人群中的结核病查和治疗策略.
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